Why the study?
Does direct gene transfer of HSP 70 reduce infarct size in vivo after ischemia/reperfusion in rabbit hearts?
Population
Rabbit hearts subjected to 30 minutes of ischemia and 3 hours of reperfusion
Comparison
Ad.HSP70 injected at 3 sites (1.5x10 pfu, 50… vs Vehicle or Ad.lacZ injection
Design
Preclinical
Follow-up
4 days after injection, followed by 30 minutes of ischemia…
Authors
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HSP70 gene transfer may limit infarct size in rabbit I/R; leaves open translation to clinical cardioprotection.
Does direct gene transfer of HSP 70 reduce infarct size in vivo after ischemia/reperfusion in rabbit hearts?
Direct gene delivery of HSP 70 in vivo significantly reduces infarct size following ischemia/reperfusion injury in a rabbit model.
Okubo et al. (2001) studied this question.
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