February 22, 2012Journal of NeuroinflammationOpen Access

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

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Population

Male C57BL-6 mice, weighing 20-25 g, subjected to an MPTP-induced Parkinson's disease model.

Comparison

Telmisartan and/or GW9662, or genetic AT1a… vs Vehicle treatment or MPTP alone.

Design

Preclinical

Follow-up

1 week after MPTP treatment

Authors

PGPablo Garrido‐GilUniversidade de Santiago de Compostela BJBelen JoglarMorpho (United States)ARAna I. Rodríguez‐PérezUniversidade de Santiago de Compostela

Discussion

Member takes

Implication

Hypothesis-generating for PPAR-γ-mediated neuroprotection in Parkinson's; leaves open translation to human disease.

Structured PICO

Population

Male C57BL-6 mice (wild type and AT1a-null), weighing 20-25 g (7 weeks old), subjected to an MPTP-induced Parkinson's disease model (n=103).

Intervention

Telmisartan (5 mg/kg/day orally) and/or GW9662 (PPAR-γ antagonist, 4 mg/kg intraperitoneally), or genetic AT1a receptor deletion.

Comparator

Vehicle treatment or MPTP alone.

Outcome

Dopaminergic cell death (number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra compacta) and microglial activation.surrogate

Telmisartan provides neuroprotection and anti-inflammatory effects in a mouse model of Parkinson's disease, mediated by PPAR-γ activation rather than solely through AT1 receptor blockade.

Cite This Study

Garrido‐Gil et al. (2012) studied this question.

synapsesocial.com/papers/6a7212495d37378ac1df0063 https://doi.org/10.1186/1742-2094-9-38

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Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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