The study characterizes the PR10 viral agent as the prototype strain of ECHO-32, detailing its physical and biological properties.
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ECHO-32 characterization aligns with enterovirus criteria without animal disease; extends taxonomy but leaves open human relevance.
A viral agent, PR10, isolated from a Puerto Rican infant with gastroenteritis has been designated as the prototype strain of ECHO-32 by the Panel for Picorna-viruses (3). ECHO-3 2 (1) produced entero-virus-like CPE in rhesus monkey kidney tissue cultures, (2) bore no antigenic relationship to known enteroviruses, (3) produced no disease in the common laboratory animals or embryonated eggs, (4) was insensitive to desoxycholate or ether, (5) was stabilized by M MgCl2 to heating at 50°C for one hour, (6) demonstrated a red staining reaction with acridine orange indicating an RNA core, and (7) was estimated to be 26-27 mμ in size.
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Branche et al. (1965) studied this question.
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