COVID-19 infection may trigger severe prothrombotic states leading to subacute in-stent thrombosis in patients with recent PCI, even on optimal dual antiplatelet therapy.
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Post-PCI in-stent thrombosis after COVID-19 may signal heightened thrombotic risk; this single case leaves open any causal or therapeutic implications.
We present a case of a 75-year-old male who underwent percutaneous coronary intervention in the setting of acute myocardial infarction with ST-segment elevation and who was hospitalized 12 days afterwards with COVID-19 pneumonia. Later the patient presented himself again with acute coronary syndrome with ST-segment elevation in the same region due to in-stent thrombosis. Transient atrioventricular conduction disorders were registered before and after the percutaneous coronary intervention. Possible pathophysiological mechanisms of the in-stent thrombosis following COVID-19 infection are discussed.
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Marinova et al. (2021) studied this question.
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