Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy

Figures

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  Figure 1. Diabetic cardiomyopathy network.

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  Figure 2. Cluster of diabetic cardiomyopathy network.

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  Figure 3. Pathway of diabetic cardiomyopathy network (Blue circle stands for breast cancer gene. Red diamond stands for pathway).

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  Figure 4. Compound-compound target network of SMP consist of 400 compound targets and 40 compounds (Pink hexagon stand for compound targets; The circles with different colors stand for compounds of different herbs: orange circle – Schisandra chinensis, Schisandraceae, yellow circle – Ophiopogon japonicas, Liliaceae, blue circle – Panax ginseng, Araliaceae. Red diamond stands for common compound of Schisandra chinensis, Schisandraceae and Panax ginseng, Araliaceae).

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  Figure 5. SMP-DCM network (Pink, blue, purple circle stand for compound target, DCM genes, DCM-compound target, resp.).

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  Figure 6. Cluster of SMP-DCM network (Pink, blue, purple circle stands for compound target, DCM genes and compound-DCM target, resp.).

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  Figure 7. Pathway o of SMP-DCM network (Blue circle stands for compound target. Red diamond stands for pathway. The hexagons with different colors stand for compounds of different herbs: orange hexagon – Schisandra chinensis, Schisandraceae, yellow hexagon – Ophiopogon japonicas, Liliaceae, blue hexagon – Panax ginseng, Araliaceae. Red triangle stands for common compound of Schisandra chinensis, Schisandraceae and Panax ginseng, Araliaceae).

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  Figure 8. Compound-known target network (Blue hexagon stand for known target. The representative of red, orange circle, and purple and red diamond is the same as Figure 4).

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  Figure 9. SMP known target-DCM network (Pink, blue, purple circle stand for known target, DCM genes, DCM-compound target, resp.).

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  Figure 10. Cluster of SMP known target-DCM network (Pink, blue, purple circle stands for known target, DCM genes and known-DCM target, resp.).

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  Figure 11. Pathway o of SMP known target-DCM network (Blue circle stands for known target. Red diamond stands for pathway. Yellow, green hexagon stand for Schisandra chinensis, Schisandraceae, Panax ginseng, Araliaceae, rep.).