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March 1, 1995AJP Renal Physiology

Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system

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Population

Primary proximal tubule (PT) cells prepared from male Wistar rats (4-5 wk old)

Design

Preclinical

Authors

STS. S. TangMassachusetts General HospitalFJF. JungBrandenburg University of Technology Cottbus-SenftenbergDDDaniel DiamantPediatric Nephrology of Alabama

Discussion

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Implication

New cell line enables PT RAS studies in vitro; leaves open translation to human physiology or therapy.

Structured PICO

P
Population
Primary proximal tubule (PT) cells prepared from male Wistar rats (4-5 wk old)
I
Intervention
Transfection with temperature-sensitive SV40 mutant viruses (tsA SV40)
O
Outcome
Establishment and characterization of the immortalized cell line, including expression of PT markers and renin-angiotensin system componentssurrogate

The establishment of a temperature-sensitive immortalized rat proximal tubule cell line provides a novel in vitro model for studying the cellular and molecular biology of the renal renin-angiotensin system.

Cite This Study

Tang et al. (1995) studied this question.

synapsesocial.com/papers/6a721c6dabc331a85807b5e1https://doi.org/10.1152/ajprenal.1995.268.3.f435
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback1999 · 118 citations
  2. 2Essential Role(s) of the Intrarenal Renin-Angiotensin System in Transforming Growth Factor–β1 Gene Expression and Induction of Hypertrophy of Rat Kidney Proximal Tubular Cells in High Glucose2002 · 47 citations
  3. 3Characterisation of the Expression of the Renin-Angiotensin System in Primary and Immortalised Human Renal Proximal Tubular Cells2010 · 12 citations
  4. 4Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium1993 · 68 citations
  5. 5Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells1995 · 27 citations