Why the study?
Does live, enteric-coated adenovirus type 21 vaccine induce systemic and local immune responses?
Population
15 subjects (10 vaccinees and 5 controls)
Comparison
Live, enteric-coated adenovirus type 21 vaccine vs Control group (n=5)
Design
Cohort
Authors
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May support enteric ADV-21 vaccine development; leaves open durability, nasal responses, and clinical protection in larger trials.
Does live, enteric-coated adenovirus type 21 vaccine induce systemic and local immune responses?
Enteric immunization with live ADV-21 vaccine induces systemic humoral and local intestinal IgA responses, but lacks nasal IgA responses, suggesting protection depends primarily on humoral antibody.
Scott et al. (1972) studied this question.
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