Why the study?
Do adrenergic-receptor blockers induce favorable changes in myocardial gene expression associated with reverse-remodeling in patients with idiopathic dilated cardiomyopathy?
Do adrenergic-receptor blockers induce favorable changes in myocardial gene expression associated with reverse-remodeling in patients with idiopathic dilated cardiomyopathy?
Reverse-remodeling in idiopathic dilated cardiomyopathy treated with beta-blockers is associated with favorable changes in calcium-handling, sarcomeric, adrenergic signaling, and metabolic genes.
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Supports beta-blocker use in idiopathic dilated cardiomyopathy; extends RCT evidence to coordinated calcium-handling, sarcomeric, and metabolic gene shifts.
Kao et al. (2015) studied this question.
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