Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents
Key result
Beta-blocker therapy in idiopathic dilated cardiomyopathy improved left ventricular ejection fraction in 26 of 32 patients, which was associated with favorable changes in myocardial gene expression.
Why the study?
Does beta-blocker therapy alter myocardial gene expression and improve left ventricular ejection fraction in patients with idiopathic dilated cardiomyopathy?
Population
53 patients with idiopathic dilated cardiomyopathy
Comparison
Beta-adrenergic-receptor blocking agent for 6… vs Placebo
Design
RCT, randomly assigned
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Supports beta-blocker use in idiopathic dilated cardiomyopathy; extends evidence by linking benefit to myocardial gene expression changes.
Study Design
Type
RCT (n=53)
Randomization
Randomized
Structured PICO
Does beta-blocker therapy alter myocardial gene expression and improve left ventricular ejection fraction in patients with idiopathic dilated cardiomyopathy?
P
Population
53 patients with idiopathic dilated cardiomyopathy
I
Intervention
Beta-adrenergic-receptor blocking agent (metoprolol or carvedilol) for 6 months
C
Comparator
Placebo
O
Outcome
Changes in myocardial gene expression (mRNA for contractility-regulating and hypertrophy-associated genes) and left ventricular ejection fraction at 6 monthssurrogate
Functional improvement from beta-blocker therapy in idiopathic dilated cardiomyopathy is associated with favorable alterations in myocardial gene expression regulating contractility and hypertrophy.
Cite This Study
Lowes et al. (2002) conducted an RCT in Idiopathic dilated cardiomyopathy (n=53). Beta-adrenergic-receptor blocking agent (metoprolol or carvedilol) vs. Placebo was evaluated on Changes in gene expression compared with changes in left ventricular ejection fraction. Beta-blocker therapy in idiopathic dilated cardiomyopathy improved left ventricular ejection fraction in 26 of 32 patients, which was associated with favorable changes in myocardial gene expression.