Why the study?
Does ischemic preconditioning reduce arrhythmias in an isolated guinea pig ventricular tissue model of ischemia and reperfusion?
Population
Isolated paced guinea pig right ventricular free walls
Comparison
Ischemic preconditioning vs Control preparations (no preconditioning)
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Does not support clinical use; leaves open translation of 5-min preconditioning effects to human ischemia-reperfusion arrhythmias.
Does ischemic preconditioning reduce arrhythmias in an isolated guinea pig ventricular tissue model of ischemia and reperfusion?
Ischemic preconditioning for 5 minutes attenuates ischemia- and reperfusion-induced arrhythmias by preventing transmural conduction delays necessary for reentry in a guinea pig model.
Zhu et al. (1998) studied this question.
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