May 1, 1978Circulation ResearchOpen Access

Baroreceptor dynamics and their relationship to afferent fiber type and hypertension.

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Population

In vitro rat aortic arch-aortic nerve preparation from normotensive rats and spontaneously hypertensive rats

Comparison

Small amplitude sinusoidal pressures applied at… vs Comparison between myelinated and unmyelinated…

Design

Preclinical

Authors

ABA M BrownDartmouth College WSW R SaumGeorgetown University SYShin YasuiChiba University

Discussion

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Implication

Baroreceptor dynamics appear unaltered by hypertension in rats; leaves open translation to human baroreflex mechanisms.

Structured PICO

Population

In vitro rat aortic arch-aortic nerve preparation from normotensive rats (NTRs) and spontaneously hypertensive rats (SHRs)

Intervention

Small amplitude sinusoidal pressures applied at frequencies varying from 0.1 to 20 Hz

Comparator

Comparison between myelinated (MBs) and unmyelinated (UBs) axons, and between NTRs and SHRs

Outcome

Dynamic characteristics (gain, phase, discharge rate) of baroreceptorssurrogate

The dynamic response differences between myelinated and unmyelinated baroreceptors are likely due to structural differences in their endings, independent of hypertension status.

Cite This Study

Brown et al. (1978) studied this question.

synapsesocial.com/papers/6a72254122b3175134db6fc3 https://doi.org/10.1161/01.res.42.5.694

Topics

Hypertension management

View Full Paper

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Baroreceptor dynamics and their relationship to afferent fiber type and hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Baroreceptor dynamics and their relationship to afferent fiber type and hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider