Why the study?
Does molecular hybridization using poliovirus subgenomic riboprobes accurately detect enteroviruses in clinical samples?
Population
Crude clinical specimens from patients with meningitis, and cell cultures.
Design
Other
Authors
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Low direct sensitivity limits routine diagnostic use without culture; leaves open refinement of hybridization assays for enterovirus detection.
Does molecular hybridization using poliovirus subgenomic riboprobes accurately detect enteroviruses in clinical samples?
Molecular hybridization using poliovirus riboprobes offers high specificity but variable sensitivity for detecting enteroviruses directly in clinical samples, performing better after cell culture amplification.
Petitjean et al. (1990) studied this question.
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