March 1, 2002AJP Renal Physiology

Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency

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Population

Rats fed a low-salt diet or treated for 1 wk with ramipril in combination with a low-salt diet

Comparison

Renal denervation or beta-adrenoreceptor… vs Intact renal nerves / no metoprolol

Design

Preclinical

Follow-up

1 week

Authors

KHKlaus HöcherlFriedrich-Alexander-Universität Erlangen-Nürnberg MKMartin KammerlDeggendorf Institute of Technology FKFrieder KeesUniversity of Regensburg

Discussion

Member takes

Implication

Does not support altering therapy; leaves open whether sympathetic-nNOS links apply to human cardiorenal disease.

Structured PICO

Population

Rats fed a low-salt (0.02% wt/wt) diet or treated for 1 wk with ramipril (10 mg/kg body wt) in combination with a low-salt diet

Intervention

Renal denervation or beta-adrenoreceptor antagonist metoprolol (50 mg/kg body wt po, twice a day)

Comparator

Intact renal nerves / no metoprolol

Outcome

Renocortical mRNA levels of renin, COX-2, and nNOSsurrogate

Beta-adrenergic stimulation or renal nerve activity is required for full stimulation of nNOS expression, but not renin or COX-2, during salt deficiency in rats.

Cite This Study

Höcherl et al. (2002) studied this question.

synapsesocial.com/papers/6a7227ccf44fa9f079dfbac4 https://doi.org/10.1152/ajprenal.00209.2001

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Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider