June 1, 1996AJP Renal Physiology
Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt
Population
Sprague-Dawley rats
Comparison
Low salt diet or high salt diet vs Control diet containing 0.2% Na
Design
Preclinical
Follow-up
7 days
Authors
Discussion
Loading...
Member takes
Implication
Animal data link dietary salt to macula densa ncNOS; hypothesis-generating and should not change clinical practice.
Structured PICO
P
Population
Sprague-Dawley rats
I
Intervention
Low salt diet (single injection of furosemide 2 mg/kg i.p. and 0.03% Na diet for 7 days) or high salt diet (3% Na diet plus 0.45% NaCl in drinking fluid for 7 days)
C
Comparator
Control diet containing 0.2% Na
O
Outcome
mRNA expression of neuronal constitutive nitric oxide synthase (ncNOS), renin, and angiotensinogen in the kidneysurrogate
Dietary salt intake inversely regulates ncNOS expression in macula densa cells, mirroring the response of the renin-angiotensin system to changes in salt balance.
Cite This Study
Singh et al. (1996) studied this question.