Dietary salt loading decreases the expressions of neuronal-type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice.

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Population

Angiotensinogen gene-knockout (Atg-/-) mice and wild-type (Atg+/+) mice

Comparison

Low-salt, normal-salt, or high-salt diet for 2… vs Normal-salt diet and wild-type mice

Design

Preclinical

Follow-up

2 weeks

Authors

Discussion

Supports further exploration of angiotensin-independent salt pathways in models; should not yet alter clinical salt recommendations.

Population

Angiotensinogen gene-knockout (Atg-/-) mice and wild-type (Atg+/+) mice

Intervention

Low-salt (0.04% NaCl), normal-salt (0.3% NaCl), or high-salt (4% NaCl) diet for 2 weeks

Comparator

Normal-salt diet and wild-type mice

Outcome

Renal expressions of N-NOS and renin (mRNA levels and histochemical staining)surrogate

Dietary salt loading decreases renal N-NOS and renin expressions independently of angiotensin formation in angiotensinogen gene-knockout mice.

Kihara et al. (1998) studied this question.

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