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May 1, 1965Experimental Biology and Medicine

Differentiation of 19S and 7S Complement Fixing Antibodies in Primary Versus Recrudescent Typhus by Either Ethanethiol or Heat.

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Population

Sera from patients with primary and secondary typhus infections

Design

Other

Authors

EME. S. MurrayUniversity of SarajevoJOJacqueline M. O’ConnorUniversity of SarajevoJGJ. A. GaonUniversity of Sarajevo

Discussion

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Implication

May enable serological distinction of antibody classes in typhus; hypothesis-generating and should not yet alter diagnostics.

Structured PICO

P
Population
Sera from patients with primary and secondary typhus infections
I
Intervention
Ethanethiol or 60°C inactivation
O
Outcome
Differentiation of 19S and 7S complement fixing (CF) antibodiessurrogate

The complement fixation test can be modified using ethanethiol or heat to differentiate 19S and 7S antibodies in typhus infections.

Cite This Study

Murray et al. (1965) studied this question.

synapsesocial.com/papers/6a7229a635aa2c282ce31d57https://doi.org/10.3181/00379727-119-30161
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serologic Studies of Primary Epidemic Typhus and Recrudescent Typhus (Brill-Zinsser Disease)1965 · 9 citations
  2. 2Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting1994 · 62 citations
  3. 3Kinetics and Magnitude of Antibody Responses against the Conserved 47-Kilodalton Antigen and the Variable 56-Kilodalton Antigen in Scrub Typhus Patients2011 · 33 citations
  4. 4Serologic Reactivity of Certain Antigens Obtained by Fractionation of Coxsackie Viruses in Cesium Chloride Density Gradients1963 · 29 citations
  5. 5Fluorescent Antibody Methods in the Differentiation of Murine and Epidemic Typhus Sera; Specificity Changes Resulting from Previous Immunization1959 · 40 citations