Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 20, 2011Clinical and Vaccine ImmunologyOpen Access

Kinetics and Magnitude of Antibody Responses against the Conserved 47-Kilodalton Antigen and the Variable 56-Kilodalton Antigen in Scrub Typhus Patients

View Full Paper
Ask AI
Bookmark
Share

Population

108 scrub typhus patients (sera from serial bleedings)

Design

Cohort

Authors

HCHuawei ChenZhejiang Sci-Tech UniversityZZZhiwen ZhangNanjing University of Science and TechnologyEHErin HuberUniformed Services University of the Health Sciences

Discussion

Loading...

Member takes

Implication

May aid differentiation of primary from secondary scrub typhus; hypothesis-generating and requires prospective validation.

Structured PICO

P
Population
108 scrub typhus patients (sera from serial bleedings)
O
Outcome
Kinetics and magnitude of specific antibody responses (IgM and IgG) against the 47-kDa (r47b) and 56-kDa (r56s) antigenssurrogate

This study characterizes three distinct patterns of antibody response kinetics against the conserved 47-kDa and variable 56-kDa antigens in scrub typhus patients, which may help differentiate primary from secondary infections.

Cite This Study

Chen et al. (2011) studied this question.

synapsesocial.com/papers/6a7424c8ca963d7f80391cc5https://doi.org/10.1128/cvi.00017-11
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of Cross-Reactive Epitopes on the Conserved 47-Kilodalton Antigen of<i>Orientia tsutsugamushi</i>and Human Serine Protease2009 · 28 citations
  2. 2Antigens of scrub typhus rickettsiae: separation by polyacrylamide gel electrophoresis and identification by enzyme-linked immunosorbent assay1981 · 24 citations
  3. 3Production and Characterization of Monoclonal Strain‐Specific Antibodies against Prototype Strains of <i>Rickettsia tsutsugamushi</i>1986 · 39 citations
  4. 4Immunogenicity of a 40kDa Fragment of the 47kDa Recombinant Protein and DNA Vaccine from Karp Strain of Orientia tsutsugamushi2003 · 10 citations
  5. 5Phylogenetic Characterization of Orientia tsutsugamushi Isolated in Taiwan According to the Sequence Homologies of 56‐kDa Type‐Specific Antigen Genes2003 · 31 citations