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March 17, 2009Infection and Immunity

Identification of Cross-Reactive Epitopes on the Conserved 47-Kilodalton Antigen ofOrientia tsutsugamushiand Human Serine Protease

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Population

Scrub typhus patient sera

Design

Preclinical

Authors

HCHuawei ChenZhejiang Sci-Tech UniversityZZZhiwen ZhangUniversity of Science and Technology of ChinaEHErin HuberUniformed Services University of the Health Sciences

Discussion

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Implication

Cross-reactivity with hHtrA1 may signal autoimmune risk for Orientia vaccines; leaves open need for human safety validation.

Structured PICO

P
Population
Scrub typhus patient sera
I
Intervention
Testing reactivity with purified recombinant 47-kDa (HtrA) and human serine protease HtrA1 (hHtrA1) proteins
O
Outcome
Reactivity of scrub typhus patient sera with recombinant hHtrA1 and 47-kDa proteinssurrogate

The 47-kDa antigen of Orientia tsutsugamushi exhibits cross-reactivity with human serine protease HtrA1, raising safety concerns for its use as a vaccine candidate due to potential autoimmune responses.

Cite This Study

Chen et al. (2009) studied this question.

synapsesocial.com/papers/6a7424c8ca963d7f80391cc6https://doi.org/10.1128/iai.01298-08
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of the Cross-Reactivity of Various 56 kDa Recombinant Protein Antigens with Serum Samples Collected after Orientia tsutsugamushi Infection by ELISA2011 · 24 citations
  2. 2Analysis of outer membrane protein from Orientia tsutsugamushi for epitope mining2025
  3. 3Diversity of the 47-kD HtrA Nucleic Acid and Translated Amino Acid Sequences from 17 Recent Human Isolates of Orientia2013 · 54 citations
  4. 4Kinetics and Magnitude of Antibody Responses against the Conserved 47-Kilodalton Antigen and the Variable 56-Kilodalton Antigen in Scrub Typhus Patients2011 · 33 citations
  5. 5A Multi-epitope Subunit Vaccine Identification and Development Against Scrub Typhus (Orientia tsutsugamushi) Using Immunoinformatics Approaches2024 · 2 citations