Population
Myosin molecules (in vitro)
Design
Preclinical
Authors
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Proline-mediated myosin unfolding may accelerate early proteolysis in muscle; leaves open relevance to cardiac myosin turnover in vivo.
Proline residues in the myosin rod appear to open a segment of the α-helical conformation, making it more susceptible to early proteolytic attack by trypsin and chymotrypsin.
Segal et al. (1967) studied this question.
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