Why the study?
Do adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide reduce calcification in cultured rat vascular smooth muscle cells?
Population
Cultured rat vascular smooth muscle cells (VSMCs) stimulated with beta-glycerophosphate
Comparison
Adrenomedullin, C-type natriuretic peptide, and… vs Beta-glycerophosphate alone (implied control)
Design
Preclinical
Authors
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May warrant preclinical follow-up for vascular calcification; leaves open translation to human disease.
Do adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide reduce calcification in cultured rat vascular smooth muscle cells?
Adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide inhibit beta-glycerophosphate-induced calcification in rat vascular smooth muscle cells via cAMP/PKA and cGMP/PKG pathways, providing potential new targets for treating vascular calcification.
Huang et al. (2003) studied this question.
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