Why the study?
African swine fever virus poses a serious threat to global swine populations, underscoring an urgent need for effective preventive strategies and vaccine development.
This review provides a comprehensive overview of host immune responses to African swine fever virus and the challenges in developing an effective vaccine.
Review synthesizes ASFV immunity data; leaves open optimal vaccine targets for further study.
The African swine fever virus (ASFV) poses a serious threat to global swine populations, underscoring the urgent need for effective preventive strategies. This comprehensive review investigates the intricate interplay between innate, cellular, and humoral immunity against ASFV, with a focus on their relevance to vaccine development. By delving into immunopathogenesis and immunological challenges, this review article aims to provide a holistic perspective on the complexities of ASFV infections and immune evasion. Key findings underscore the critical role of innate immune recognition in shaping subsequent adaptive immune defenses, potential protective antigens, and the multifaceted nature of ASFV-specific antibodies and cytotoxic T-cell responses. Despite advancements, the unique attributes of ASFV present hurdles in the development of a successful vaccine. In conclusion, this review examines the current state of ASFV immune responses and offers insights into future research directions, fostering the development of effective interventions against this devastating pathogen.
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Fredmoore L. Orosco (2023) studied this question.
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