September 5, 2008FEBS LettersOpen Access

African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP‐K) during infection

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Population

Macrophage cDNA library and cells infected with African swine fever virus (ASFV) or transiently expressing p30

Design

Preclinical

Authors

Discussion

May indicate ASFV p30 mechanism for host RNA suppression; leaves open its necessity in viral pathogenesis.

Population

Macrophage cDNA library and cells infected with African swine fever virus (ASFV) or transiently expressing p30

Intervention

ASFV infection or transient expression of p30

Outcome

Interaction between p30 and hnRNP-K, subcellular distribution, and incorporation of 5-fluorouridine into nascent RNAsurrogate

The interaction between ASFV protein p30 and hnRNP-K provides a possible mechanism by which the virus downregulates host cell mRNA translation.

Hernáez et al. (2008) studied this question.

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