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February 1, 2003Hemodialysis International

Acute Postdialysis Changes in Plasma ICAM-1 and IL-1 Levels in Hemodialysis Patients

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Why the study?

Does the type of hemodialysis membrane or dialysate affect acute changes in plasma ICAM-1 and IL-1β levels in hemodialysis patients?

Population

50 subjects: 30 hemodialysis patients and 20 controls

Comparison

Hemodialysis using cuprophane or polysulfone… vs Healthy controls; comparison between membrane…

Design

Cohort

Follow-up

Immediately after dialysis

Authors

SES EL-HefeniAlexandria UniversityTMT MoghazyAlexandria UniversityMRMohamed RagabBeni-Suef University

Discussion

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Implication

Bioincompatible membranes associate with greater inflammation in HD; observational data leaves open effects on clinical outcomes and need for RCTs.

Structured PICO

Does the type of hemodialysis membrane or dialysate affect acute changes in plasma ICAM-1 and IL-1β levels in hemodialysis patients?

P
Population
50 subjects: 30 hemodialysis patients and 20 controls
I
Intervention
Hemodialysis using cuprophane (bioincompatible) or polysulfone (biocompatible) membranes, and acetate or bicarbonate dialysate
C
Comparator
Healthy controls (for baseline); comparison between membrane and dialysate types within the patient group
O
Outcome
Acute changes in plasma ICAM-1 and IL-1β levels immediately after dialysissurrogate

Bioincompatible hemodialysis membranes induce a significantly greater acute inflammatory response, as measured by IL-1β levels, compared to biocompatible membranes.

Cite This Study

EL-Hefeni et al. (2003) studied this question.

synapsesocial.com/papers/6a723feb26a7f98052de3393https://doi.org/10.1046/j.1492-7535.2003.01259.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Interleukin-1 Activity during Hemodialysis: The Influence of Dialysis Membranes2008 · 71 citations
  2. 2Membrane Bioincompatibility and Ultrafiltration Effects on Pulse Wave Analysis during Haemodialysis2012
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  4. 4#2866 The CompAct-HD trial reports a persistent inflammatory profile in patients undergoing haemodialysis, acutely exacerbated with each treatment2024 · 1 citations
  5. 5A POTENTIAL ROLE FOR IMMUNE ACTIVATION IN HEMODIALYSIS HYPOTENSION2001 · 14 citations