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January 1, 2001Renal FailureOpen Access

A Potential Role for Immune Activation in Hemodialysis Hypotension

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Why the study?

Is immune activation associated with intradialytic hypotension in hemodialysis patients?

Population

17 hemodialysis patients

Comparison

Hemodialysis vs Hemodialysis patients without a history of…

Design

Cross-sectional

Authors

MTMichiyo TomitaUniversity of Toledo Medical CenterDMDeepak MalhotraUniversity of Toledo Medical CenterSDSunita DheenanUniversity of Toledo Medical Center

Discussion

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Implication

May support immune activation in hypotension-prone hemodialysis patients; leaves open causal confirmation in prospective studies.

Structured PICO

Is immune activation associated with intradialytic hypotension in hemodialysis patients?

P
Population
17 hemodialysis patients (9 consecutive patients with a history of symptomatic hypotension during hemodialysis, and 8 consecutive hemodialysis patients without intradialytic hypotension)
I
Intervention
Hemodialysis (observational assessment of immune activation markers CRP and IL-6)
C
Comparator
Hemodialysis patients without a history of intradialytic hypotension
O
Outcome
Correlation between maximum percent change in mean arterial pressure (MAP) and immune activation markers (CRP and IL-6)surrogate

Immune activation, potentially mediated by IL-6 and CRP, may play a role in the pathogenesis of hemodialysis-induced hypotension in susceptible patients.

Cite This Study

Tomita et al. (2001) studied this question.

synapsesocial.com/papers/6a9c3d7d57420109d4cb03d5https://doi.org/10.1081/jdi-100107360
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