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December 9, 2008˜The œNephron journals/Nephron journals

Plasma Interleukin-1 Activity during Hemodialysis: The Influence of Dialysis Membranes

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Why the study?

How do different hemodialysis membranes affect plasma interleukin-1 activity in stable ESRD patients?

Population

7 stable ESRD patients on regular hemodialysis for no less than 5 months, and 8 normal control subjects.

Comparison

Hemodialysis with four different membranes. vs Comparison between different dialysis membranes…

Design

Cohort

Authors

MBMarion BingelLeibniz University HannoverGLGerhard LonnemannLeibniz University HannoverKKKarl KochRussian State Social University

Discussion

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Implication

Membrane-specific IL-1 changes in hemodialysis should not yet alter practice; hypothesis-generating for bioincompatibility mechanisms.

Structured PICO

How do different hemodialysis membranes affect plasma interleukin-1 activity in stable ESRD patients?

P
Population
7 stable ESRD patients on regular hemodialysis for no less than 5 months, and 8 normal control subjects.
I
Intervention
Hemodialysis with four different membranes (Cuprophan, Hemophan, Gambrane, and Polysulfon).
C
Comparator
Comparison between different dialysis membranes and normal control subjects.
O
Outcome
Plasma interleukin-1 (IL-1) activity.surrogate

Different hemodialysis membranes have varying effects on plasma IL-1 activity, which may be due to differences in their ability to remove or absorb IL-1 rather than variable monocyte stimulation.

Cite This Study

Bingel et al. (2008) studied this question.

synapsesocial.com/papers/6a8bde1b60c8c47a9ee3eed3https://doi.org/10.1159/000185186
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Also Consider

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  1. 1Acute Postdialysis Changes in Plasma ICAM-1 and IL-1 Levels in Hemodialysis Patients2003 · 1 citations
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  3. 3A POTENTIAL ROLE FOR IMMUNE ACTIVATION IN HEMODIALYSIS HYPOTENSION2001 · 14 citations
  4. 4Prevalence of depression symptoms and serum levels of interleukin‐6 in hemodialysis patients2013 · 24 citations
  5. 5Hypervolemia-Induced immune disturbances do not involve IL-1ß but IL-6 and IL-10 activation in Haemodialysis patients2020