Population
Young adult normotensive Wistar-Kyoto and spontaneously hypertensive rats, aged 16 weeks by the end of the…
Design
Preclinical
Follow-up
8 weeks
Authors
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Salt excess may promote diastolic dysfunction in hypertension; hypothesis-generating in rat models and leaves clinical translation open.
Salt loading in spontaneously hypertensive rats induces biventricular diastolic dysfunction, myocardial fibrosis, and impaired coronary hemodynamics through nonhemodynamic mechanisms.
Varagić et al. (2005) studied this question.
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