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July 1, 1997The Journal of General PhysiologyOpen Access

Effect of Alkali Metal Cations on Slow Inactivation of Cardiac Na+ Channels

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Population

Human heart Na+ channels (F1485Q mutant) expressed transiently in mammalian cells and Xenopus oocytes

Comparison

Extracellular alkali metal cations and high… vs Extracellular organic cations and low…

Design

Preclinical

Authors

CTClaire TownsendGlaxoSmithKline (United States)RHRichard HornSequans Communications (United Kingdom)

Discussion

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Implication

No immediate clinical implications; leaves open whether extracellular Na+ regulates slow inactivation in native cardiac tissue.

Structured PICO

P
Population
Human heart Na+ channels (F1485Q mutant) expressed transiently in mammalian cells and Xenopus oocytes
I
Intervention
Extracellular alkali metal cations (Li+, Na+, K+, Rb+, Cs+) and high extracellular Na+ (150 mM)
C
Comparator
Extracellular organic cations (Tris, tetramethylammonium, N-methylglucamine, choline) and low extracellular Na+ (10 mM)
O
Outcome
Kinetics of slow inactivation of Na+ currents (decay rate, recovery rate, single channel kinetics)surrogate

Alkali metal cations inhibit the closing of the slow inactivation gate in human cardiac Na+ channels, likely through binding in the ion-conducting pore.

Cite This Study

Townsend et al. (1997) studied this question.

synapsesocial.com/papers/6a724811e5469ee92be257achttps://doi.org/10.1085/jgp.110.1.23
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anomalous Effect of Permeant Ion Concentration on Peak Open Probability of Cardiac Na+ Channels1997 · 29 citations
  2. 2Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.1994 · 142 citations
  3. 3Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.1991 · 442 citations
  4. 4Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation1990 · 1,553 citations
  5. 5Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels1974 · 752 citations