Population
Human heart Na+ channels expressed transiently in mammalian cells and Xenopus oocytes
Comparison
Decreased extracellular permeant ion concentration vs High concentrations of extracellular permeant…
Design
Preclinical
Authors
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Challenges standard Na+ channel gating models in vitro; leaves open relevance to native myocytes or antiarrhythmic mechanisms.
Extracellular permeant ion concentration anomalously affects the peak open probability of cardiac Na+ channels, likely due to ion occupancy within the extracellular mouth of the pore.
Townsend et al. (1997) studied this question.
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