Why the study?
Does electrical stimulation at different sites along the vagal pathway selectively enhance parasympathetic tone to the heart while minimizing side effects in anesthetized canines?
Does electrical stimulation at different sites along the vagal pathway selectively enhance parasympathetic tone to the heart while minimizing side effects in anesthetized canines?
Selective electrical stimulation of the sinoatrial node ganglia effectively induces parasympathetic effects without the vocal cord activation and sympathetic side effects associated with whole vagus nerve or ventricular ganglia stimulation.
Objectives: Sympathetic overactivity and vagal withdrawal are cardinal presentations in patients with heart failure that predisposes them to malignant arrhythmias and sudden cardiac death.
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Scott Sayers (2013) studied this question.
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