A computational model of cerebral circulation in rats successfully simulated the physiological responses to venous hypertension caused by jugular vein ligation.
Supports rat cerebral venous hypertension modeling via variable regulatory gains; leaves open human translation.
The paper presents a model for the cerebral circulation which emphasizes the interaction among the different control mechanisms in response to the perturbation produced by ligature of both jugular veins in the rat. The model's structure is determined on the basis of present knowledge of cerebrovascular control mechanisms and on the basis of hypotheses which find aposteriori confirmation in the fitting of the model to experimental responses. After stating the hypotheses and describing the general structure of the model, the corresponding equations are illustrated in detail and justified. The results obtained through numerical simulation mimic the great diversity of experimental responses and indicate the cause to be the range of gains characterizing the regulatory processes.
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Belardinelli et al. (1985) studied this question.
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