Why the study?
Does chronic beta-adrenergic stimulation alter contractile function and regulatory cardiac proteins in hypertrophied rat hearts?
Does chronic beta-adrenergic stimulation alter contractile function and regulatory cardiac proteins in hypertrophied rat hearts?
Chronic beta-adrenergic stimulation in rats induces cardiac hypertrophy and attenuates contractile responsiveness to isoproterenol via downregulation of PLB and SERCA2 and reduced PLB phosphorylation.
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Reduced PLB phosphorylation and expression may underlie beta-adrenergic hyporesponsiveness in hypertrophy; leaves open translation to human HF.
Stein et al. (1996) studied this question.