Why the study?
Does recombinant human growth hormone improve cardiac function in a rat model of heart failure?
Population
Rat model of heart failure induced by left coronary artery ligation, and sham-operated rats
Comparison
Recombinant human growth hormone administered… vs Vehicle
Design
Preclinical
Follow-up
15 days
Authors
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Hypothesis-generating in experimental heart failure; human trials needed before any clinical consideration.
Does recombinant human growth hormone improve cardiac function in a rat model of heart failure?
Growth hormone improves cardiac performance in experimental heart failure by increasing myocardial contractility and reducing peripheral vascular resistance.
Yang et al. (1995) studied this question.
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