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March 28, 1996New England Journal of MedicineOpen Access

A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy

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Why the study?

Does recombinant human growth hormone improve cardiac hemodynamics and function in patients with idiopathic dilated cardiomyopathy and moderate-to-severe heart failure?

Population

7 patients with idiopathic dilated cardiomyopathy and moderate-to-severe heart failure

Design

Case_series

Follow-up

3 months of therapy and 3 months after discontinuation

Authors

SFSergio FazioPreventive CardiologyDSD SabatiniFederico II University HospitalBCBrunella CapaldoFederico II University Hospital

Discussion

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Implication

May improve hemodynamics in idiopathic dilated cardiomyopathy; hypothesis-generating and requires randomized confirmation before clinical use.

Structured PICO

Does recombinant human growth hormone improve cardiac hemodynamics and function in patients with idiopathic dilated cardiomyopathy and moderate-to-severe heart failure?

P
Population
7 patients with idiopathic dilated cardiomyopathy and moderate-to-severe heart failure
I
Intervention
Recombinant human growth hormone 14 IU per week for 3 months added to standard therapy for heart failure
O
Outcome
Cardiac function evaluated with Doppler echocardiography, right-heart catheterization, and exercise testingsurrogate

In a small preliminary study, recombinant human growth hormone improved hemodynamics, myocardial energy metabolism, and clinical status in patients with idiopathic dilated cardiomyopathy.

Cite This Study

Fazio et al. (1996) studied this question.

synapsesocial.com/papers/6a828fb10de57fd8eeb28375https://doi.org/10.1056/nejm199603283341301
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reversible Dilated Cardiomyopathy Due to Growth Hormone Deficiency1993 · 102 citations
  2. 2Effects of Human Growth Hormone in Men over 60 Years Old1990 · 1,576 citations
  3. 3Bioenergetic Consequences of Left Ventricular Remodeling1995 · 70 citations
  4. 4Left ventricular mechanical efficiency in man with heart disease.1977 · 41 citations
  5. 5Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts1995 · 110 citations