Why the study?
Does the molecular weight of LMWHs affect their dependence on renal clearance and potential for accumulation in patients with renal impairment?
Population
Populations with a high prevalence of renal impairment, such as the elderly and patients with cancer, based…
Comparison
High molecular weight LMWHs vs Lower molecular weight LMWHs and unfractionated…
Design
Review
Authors
Loading...
May guide LMWH selection in renal impairment; leaves open prospective outcome trials.
Does the molecular weight of LMWHs affect their dependence on renal clearance and potential for accumulation in patients with renal impairment?
LMWHs with higher molecular weights, such as tinzaparin, undergo more extensive non-renal clearance, making them potentially safer options for patients with renal insufficiency due to a lower risk of accumulation.
JOHANSEN et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: