Population
Primary cardiac myocytes derived from neonatal rats, COS7 cells, and transgenic mice expressing human p300…
Comparison
Phenylephrine stimulation, p300 overexpression… vs Saline stimulation, wild-type mice, and…
Design
Preclinical
Authors
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p300 acetylation may drive eccentric remodeling in models; leaves open its relevance as a therapeutic target in human HF.
p300-mediated nuclear acetylation of GATA-4 plays a critical role in myocyte hypertrophy and represents a pathway leading to decompensated heart failure.
Yanazume et al. (2003) studied this question.
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