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July 1, 1997Pacing and Clinical Electrophysiology

At 60 beats/min, cardiac output was higher under AAI than under DDD mode only when the stimulus-R interval was below 220 ms; exercise parameters (time to anaerobic threshold, VO2AT, and VO2AT pulse) showed no significant differences between modes.

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Why the study?

Does AAIR pacing improve cardiac output and exercise capacity compared to DDDR pacing in patients with sick sinus syndrome and impaired sinus node chronotropy?

Population

15 patients with sick sinus syndrome and impaired sinus node chronotropy, mean age 65 +/- 6 years, 10 men…

Comparison

AAIR pacing at rest and during exercise vs DDDR pacing at rest and during exercise

Design

Other

Authors

PVPanos VardasΕSΕmmanuel SimantirakisFPF. Parthenakis

Discussion

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Overview

May support AAIR over DDDR for resting output when AV conduction allows; leaves open exercise benefits in sick sinus syndrome.

Structured PICO

Does AAIR pacing improve cardiac output and exercise capacity compared to DDDR pacing in patients with sick sinus syndrome and impaired sinus node chronotropy?

P
Population
15 patients with sick sinus syndrome (SSS) and impaired sinus node chronotropy, mean age 65 +/- 6 years, 10 men, who had been paced for at least 3 months with activity sensor rate modulated dual chamber pacemakers.
I
Intervention
AAIR pacing at rest (60 and 100 beats/min) and during exercise
C
Comparator
DDDR pacing at rest (60 and 100 beats/min) and during exercise (AV delay 120 ms)
O
Outcome
Systolic and diastolic LV function, cardiac output (CO), oxygen consumption (VO2AT), and VO2AT pulse at the anaerobic thresholdsurrogate

AAIR pacing maintains a higher resting cardiac output than DDDR pacing in patients with sick sinus syndrome, provided the stimulus-R interval is not excessively prolonged, with both modes performing equally well during exercise.

Cite This Study

Vardas et al. (1997) studied this question.

synapsesocial.com/papers/6a7258b9f44fa9f079dfddf1https://doi.org/10.1111/j.1540-8159.1997.tb03564.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of Physiological Adaptation of the Atrioventricular Interval to Heart Rate in Patients Chronically Paced in the AAIR Mode1991 · 39 citations
  2. 2Comparison of Ventricular Function in Atrial Rate Adaptive Versus Dual Chamber Rate Adaptive Pacing During Exercise1994 · 11 citations
  3. 3A comparison of AAIR versus DDDR pacing for patients with sinus node dysfunction: a long-term follow-up study2021 · 5 citations
  4. 4Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias.1993 · 27 citations
  5. 5Rate adaptive pacing in sick sinus syndrome: effects of pacing modes and intrinsic conduction on physiological responses, arrhythmias, symptomatology and quality of life1994 · 23 citations