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February 26, 2021Cardiovascular journal of South Africa/Cardiovascular journal of Southern AfricaOpen Access

A comparison of AAIR versus DDDR pacing for patients with sinus node dysfunction: a long-term follow-up study

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Key result

AAIR pacing shows no difference in device sepsis or lead revision versus DDDR in SND.

  • P=0.70

Why the study?

The clinical outcomes of AAIR versus DDDR pacing in patients with sinus node dysfunction were compared to guide pacing choice based on AV nodal functional testing.

Does AAIR pacing improve clinical outcomes compared to DDDR pacing in patients with sinus node dysfunction?

Population

Patients with sinus node dysfunction undergoing pacemaker implantation

Comparison

AAIR pacing guided by AV nodal functional testing vs DDDR pacing

Design

Retrospective review of consecutive patients over 10 years

Follow-up

Long-term

Discussion

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Overview

Supports AAIR pacing after AV nodal testing as DDDR alternative in resource-limited settings; leaves open need for randomized confirmation.

Study Design

Type

Cohort

Structured PICO

Does AAIR pacing improve clinical outcomes compared to DDDR pacing in patients with sinus node dysfunction?

P
Population
Patients with sinus node dysfunction (SND)
E
Exposure
Atrial-pacing atrial-sensing inhibited-response rate-adaptive (AAIR) pacing, guided by AV nodal functional testing at implant
C
Comparator
Dual-chamber rate-adaptive (DDDR) pacing
O
Outcome
Clinical outcomes including atrial fibrillation (AF), atrio-ventricular (AV) block, device sepsis, and lead revision

Main Result

p-value: p=0.70

In patients with sinus node dysfunction, AAIR pacing guided by AV nodal functional testing is a viable alternative to DDDR pacing with a low risk of AV block or lead revision, particularly useful in resource-limited settings.

Cite This Study

A 2021 study conducted a cohort in Sinus node dysfunction (SND). AAIR pacing vs. DDDR pacing was evaluated on Clinical outcomes including atrial fibrillation (AF), atrio-ventricular (AV) block, device sepsis and lead revision (p=0.70). AAIR pacing showed no difference in device sepsis or need for lead revision compared to DDDR pacing in patients with sinus node dysfunction.

synapsesocial.com/papers/6aace4ef666e07b26a0cf38ahttps://doi.org/10.5830/cvja-2020-040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparison of single-lead atrial pacing with dual-chamber pacing in sick sinus syndrome2011 · 302 citations
  2. 2Long-term clinical performance of AAI pacing in patients with sick sinus syndrome: a comparison with dual-chamber pacing2004 · 32 citations
  3. 3Single lead atrial vs. dual chamber pacing in sick sinus syndrome: extended register-based follow-up in the DANPACE trial2016 · 35 citations
  4. 4AV Block and Changes in Pacing Mode During Long‐Term Follow‐Up of 399 Consecutive Patients with Sick Sinus Syndrome Treated with an AAI/AAIR Pacemaker2001 · 90 citations
  5. 5Atrioventricular Conduction Disturbances in Patients with Sinoatrial Node Disease and Atrial Pacing1992 · 11 citations