Key result
In sinus node disease, dual-chamber pacing (DDD) was associated with an increased risk of post-implant atrial fibrillation or flutter compared to atrial pacing (HR 1.30; 95% CI 1.10-1.52).
Why the study?
Does dual-chamber pacing (DDD) compared to atrial pacing (AAI) affect cardiovascular morbidity and mortality in patients with sinus node disease?
Cohort (n=8,777)
Yes
Does dual-chamber pacing (DDD) compared to atrial pacing (AAI) affect cardiovascular morbidity and mortality in patients with sinus node disease?
Hazard Ratio: 1.3 (95% CI 1.1–1.52)
In patients with sinus node disease, atrial pacing (AAI) is associated with lower risks of atrial fibrillation, cardiovascular disease, and all-cause mortality compared to dual-chamber pacing (DDD).
No takes yet. Share an insight, caveat, or question.
Supports atrial over dual-chamber pacing to lower AF risk in sinus node disease; leaves open effects on morbidity/mortality and need for RCTs.
Fored et al. (2008) conducted a cohort in Sinus node disease (n=8,777). Dual-chamber pacing (DDD) vs. Atrial pacing (AAI) was evaluated on Post-implant atrial fibrillation or flutter (HR 1.30, 95% CI 1.10-1.52). In sinus node disease, dual-chamber pacing (DDD) was associated with an increased risk of post-implant atrial fibrillation or flutter compared to atrial pacing (HR 1.30; 95% CI 1.10-1.52).
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