Why the study?
Does respiratory-dependent atrial pacing improve exercise performance compared to fixed-rate pacing in patients with symptomatic isolated sinus node disease?
Population
23 patients with symptomatic isolated sinus node disease, mean age 68 +/- 10 years, 11 male and 12 female.
Comparison
Respiratory-dependent atrial pacing (AAI-RD) vs Fixed rate 70 bpm atrial pacing (AAI)
Design
Case_series
Key result
Respiratory-dependent atrial pacing significantly improved total work time compared to fixed-rate AAI pacing (9.9 vs 6.8 min, P<=0.002) in patients with sinus node disease.
Authors
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Should not yet change practice in sinus node disease; hypothesis-generating for respiratory-dependent atrial pacing.
Does respiratory-dependent atrial pacing improve exercise performance compared to fixed-rate pacing in patients with symptomatic isolated sinus node disease?
Absolute Event Rate: 9.9% vs 6.8%
p-value: p=<=0.002
Respiratory-dependent atrial pacing improves exercise capacity and physiological heart rate response compared to fixed-rate pacing in a subset of patients with sinus node disease.
Rognoni et al. (1988) studied symptomatic isolated sinus node disease (SND) (n=23). Respiratory-dependent atrial pacing (AAI-RD) vs. Fixed rate AAI pacing (70 bpm) was evaluated on Total work time (min) (p=<=0.002). Respiratory-dependent atrial pacing significantly improved total work time compared to fixed-rate AAI pacing (9.9 vs 6.8 min, P<=0.002) in patients with sinus node disease.
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