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October 1, 2002Current Opinion in Lipidology

Genes potentially involved in plaque rupture

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Population

Whole mount vascular specimens and animal models (mice) exhibiting features of plaque rupture

Design

Review

Authors

BFBirgit FaberSHSylvia HeenemanMDMat J.A.P. Daemen

Discussion

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Overview

May support multi-target plaque stabilization strategies; leaves open prospective validation of specific gene targets.

Structured PICO

P
Population
Whole mount vascular specimens and animal models (mice) exhibiting features of plaque rupture
O
Outcome
Molecular mechanisms involved in plaque rupture

Plaque rupture is a multifactorial process involving extracellular matrix turnover, cell turnover, and lipid metabolism, suggesting that multi-target interventions may be most effective.

Cite This Study

Faber et al. (2002) studied this question.

synapsesocial.com/papers/6a725d89e5469ee92be26155https://doi.org/10.1097/00041433-200210000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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