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January 14, 2019Journal of Atherosclerosis and ThrombosisOpen Access

Investigation of the Underlying Genes and Mechanism of Macrophage-Enriched Ruptured Atherosclerotic Plaques Using Bioinformatics Method

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Key result

Bioinformatics analysis identified 268 differentially expressed genes between ruptured and stable atherosclerotic plaques, highlighting down-regulated COL3A1, COL1A2, and ASPN, and up-regulated PPBP.

Why the study?

The study aimed to identify the underlying differentially expressed genes and mechanism of macrophage-enriched ruptured atherosclerotic plaque using bioinformatics methods.

Comparison

Ruptured vs stable atherosclerotic samples

Design

Bioinformatics analysis of microarray dataset GSE41571

Authors

HWHao WangDLDongyuan LiuHZHongbing Zhang

Discussion

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Overview

May highlight macrophage pathways in plaque rupture; hypothesis-generating and requires functional validation before clinical translation.

Study Design

Type

Observational (n=11)

Multicenter

No

PICO

P
Population
11 macrophage-rich regions of carotid atherosclerotic samples (6 stable, 5 ruptured) from patients undergoing surgery for carotid artery stenosis.
E
Exposure / Comparator
Ruptured atherosclerotic plaques vs Stable atherosclerotic plaques
O
Primary Outcome
Differentially expressed genes (DEGs)

Limitations

  • Findings were obtained using in silico methods without experimental verification due to insufficient tissue samples.
  • Small sample size of the dataset might affect the reliability of the findings.

Cite This Study

Wang et al. (2019) conducted an observational in Atherosclerosis (n=11). Ruptured atherosclerotic plaques vs. Stable atherosclerotic plaques was evaluated on Differentially expressed genes (DEGs). Bioinformatics analysis identified 268 differentially expressed genes between ruptured and stable atherosclerotic plaques, highlighting down-regulated COL3A1, COL1A2, and ASPN, and up-regulated PPBP.

synapsesocial.com/papers/6a9652db33d7b00ae7bb7341https://doi.org/10.5551/jat.45963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis2022 · 15 citations
  2. 2Dysregulated Sheddase Signalling as a Molecular Driver of Plaque Instability Revealed by Integrative Transcriptomics2026 · 1 citations
  3. 3Genes potentially involved in plaque rupture2002 · 21 citations
  4. 4Integrated analysis of gene expression changes associated with coronary artery disease2019 · 18 citations
  5. 5Identification of key genes related to macrophages and metabolic reprogramming in myocardial infarct based on single-cell and bulk transcriptomics data and experimental validation2026