Key points are not available for this paper at this time.
Hypothesis-generating for endothelial NO modulation of alpha1 responses; leaves open relevance to human pressor control or therapy.
Increased pressor response to the infusion of alpha1-adrenoceptor agonist phenylephrine was observed in conditions of inhibited NO synthesis: the mean blood pressure increased from 33.7 to 41.1% and the total peripheral resistance increased from 6.8 to 22.0%. The effect of vasodilation induced by NO secretion in the vascular endothelium after the stimulation by alpha1-adrenoceptors on the degree of pressor changes and changes in the total peripheral resistance is proposed.
No takes yet. Share an insight, caveat, or question.
Osadchii et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: