Population
Isolated perfused heart models of ischaemia-induced ventricular fibrillation
Design
Review
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Supports isolated perfused heart for initial anti-VF screening in research; leaves open absolute clinical predictive value.
The isolated perfused heart is a valuable preclinical model for studying ischaemia-induced ventricular fibrillation and early arrhythmogenesis, though its direct translation to human sudden cardiac death prevention remains unproven.
Michael J. Curtis (1998) studied this question.
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