Key result
A new blood-perfused isolated rat heart model of regional ischaemia showed reduced arrhythmia severity compared to previous models during early and late periods of coronary artery occlusion.
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This commentary highlights the reduced severity of arrhythmias in a new blood-perfused isolated rat heart model of regional ischaemia compared to previous models.
A new model of regional ischaemia using blood-perfused isolated rat hearts is reported in this issue. This model has potential value in pharmacology to test the actions of drugs against the arrhythmias that arise early period (0-30 min) after induction of ischaemia. Unfortunately, the severity of arrhythmias in this new model is reduced, when compared to other models, in both the early and the late period (1-4 h) of coronary artery occlusion. This commentary compares the new model with previous models, and comments on the possible mechanisms of arrhythmias induced by ischaemia.
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Guppy et al. (2002) conducted an editorial in Ischaemic arrhythmias. Blood-perfused isolated rat heart model of regional ischaemia vs. Previous models was evaluated on Severity of arrhythmias. A new blood-perfused isolated rat heart model of regional ischaemia showed reduced arrhythmia severity compared to previous models during early and late periods of coronary artery occlusion.
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