Why the study?
Do halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels?
Do halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels?
Both halofantrine and its metabolite N-desbutylhalofantrine cause high-affinity block of HERG potassium channels, suggesting that the metabolite offers minimal safety margin gain regarding QT prolongation.
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Supports QT monitoring caution with halofantrine; leaves open metabolite contribution to clinical arrhythmia risk.
M Mbai (2002) studied this question.
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