Why the study?
Does halofantrine or its metabolite cause cardiotoxicity through QT interval prolongation and potassium channel blockade?
Does halofantrine or its metabolite cause cardiotoxicity through QT interval prolongation and potassium channel blockade?
Halofantrine causes cardiotoxicity by prolonging repolarization via blockade of the delayed rectifier potassium channel, similar to class III antiarrhythmics, whereas its metabolite N-desbutylhalofantrine appears safer.
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May suggest halofantrine QT risk via IKr block; leaves open human translation and metabolite safety.
David Wesche (2000) studied this question.
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