Why the study?
Do cigarette smoking and obesity interact to increase the risk of coronary heart disease in males?
Do cigarette smoking and obesity interact to increase the risk of coronary heart disease in males?
Obesity enhances the risk of coronary heart disease among white male cigarette smokers, suggesting a synergistic effect between smoking and body weight.
May heighten CHD vigilance among overweight white male smokers; hypothesis-generating for synergy and requires prospective confirmation.
In males, the incidence rate of coronary heart disease (CHD) in white noncigarette smokers was 52.7/1,000 and among blacks, 9.8/1,000; among white cigarette smokers the rate was 101/1,000 but in blacks only 32.5/1,000. The incidence rate of CHD in the leanest whites was 95.5/1,000, among the leanest blacks, 24.1/1,000; however, in the most obese whites the rate was 137/1,000 and among the blacks, 53.6/1,000. When comparing white smokers with nonsmokers in the leanest and most obese tertiles, smokers run a substantial risk of developing CHD, increasing with increase in overweight (80, 90, and 150/1,000, respectively). The risk of nonsmokers developing CHD does not increase from the leanest to the moderately overweight and the most obese group, (51, 30, and 64/1,000, respectively). Therefore, obesity in white males seems to enhance the risk of CHD among cigarette smokers but not among nonsmokers.
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Siegfried Heyden (1971) studied this question.
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