shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparision with siRNA

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Structured PICO

Population

Cultured cells and a human hepatocyte line with HCV subgenomic replicons

Intervention

in vitro-transcribed 25-bp and 19-bp shRNAs targeting the internal ribosome entry site (IRES) of HCV

Comparator

siRNAs targeting the same sequence

Outcome

Inhibition of IRES-driven gene expression and anti-HCV activitysurrogate

shRNAs targeting the HCV IRES are highly potent in vitro and may be effective agents for controlling HCV infection.

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Hypothesis-generating for shRNA antivirals in HCV; prospective human studies needed before clinical consideration.

Vlassov et al. (2007) studied this question.

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