What question did this study set out to answer?

To assess alterations in the functional activity and molecular integrity of circulating plasma fibrinogen in patients undergoing rt-PA thrombolysis for acute myocardial infarction.

February 1, 1992Blood Coagulation & Fibrinolysis

Studies on the functionality of fibrinogen during rt-PA therapy

View Full Paper

Ask AI

Bookmark

Why the study?

How does rt-PA therapy affect the functionality of fibrinogen in patients with acute myocardial infarction?

Population

12 patients with acute myocardial infarction

Design

Cohort

Follow-up

72 hours

Authors

ESE. SeifriedGoethe University Frankfurt MOMargret OethingerHennepin County Medical Center PTP. TanswellBoehringer Ingelheim (Germany)

Discussion

Member takes

Implication

Fibrinogen ratio changes with rt-PA in AMI; hypothesis-generating for clotting index utility, should not yet alter practice.

Key Points

To assess alterations in the functional activity and molecular integrity of circulating plasma fibrinogen in patients undergoing rt-PA thrombolysis for acute myocardial infarction.
Measured plasma fibrinogen levels across multiple time points up to 72 hours in 12 patients with acute myocardial infarction receiving rt-PA therapy.
Employed two functional assays (Clauss clotting rate and photometric polymerization rate) and one antigen-specific assay (enzyme immunoassay for intact fibrinogen).
Functional fibrinogen fell to 54% (Clauss: 2.2 g/l) and 59% (photometric: 2.1 g/l) at 90 minutes before rebounding to 146% (5.7 g/l) and 130% (4.5 g/l) at 72 hours, while intact antigen showed no rebound (106%, 2.7 g/l).
The ratio of functional to intact fibrinogen decreased from 1.6 at baseline to 1.0 at 90 minutes, followed by a significant surge between 8 and 24 hours to a peak of 2.1 (P < 0.01).

Structured PICO

How does rt-PA therapy affect the functionality of fibrinogen in patients with acute myocardial infarction?

Population

12 patients with acute myocardial infarction

Intervention

rt-PA therapy

Outcome

Plasma fibrinogen levels (functional and intact) measured at baseline, 90 min, and 72 hsurrogate

The ratio of functional to immunologically intact fibrinogen changes significantly during and after rt-PA therapy for acute myocardial infarction, potentially serving as an index for specific clotting activities.

Cite This Study

Seifried et al. (1992) studied this question.

synapsesocial.com/papers/6a726a20ac440176ef2aa94d https://doi.org/10.1097/00001721-199202000-00012

View Full Paper

Ask AI

Bookmark

Studies on the functionality of fibrinogen during rt-PA therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Studies on the functionality of fibrinogen during rt-PA therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider