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November 3, 1997FEBS Letters

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG

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Authors

DRDavid RampeSanofi (United States)MRMary Louise RoyThe University of Queensland ADAdrienne T. DennisMetroHealth Medical Center

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Implication

High-affinity HERG blockade by cisapride explains QT prolongation risk; leaves open contributions of other channels in clinical settings.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Rampe et al. (1997) studied this question.

synapsesocial.com/papers/6a726b5e84cc45bb7be01e70 https://doi.org/10.1016/s0014-5793(97)01249-0

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cisapride‐induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres1996 · 98 citations
2Long QT Syndrome During High-Dose Cisapride1995 · 164 citations
3Cisapride-induced dysrhythmia in a pediatric patient receiving extracorporeal life support1996 · 34 citations
4Potassium channel blockers as antiarrhythmic drugs1994 · 49 citations
5Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.1993 · 353 citations